Our Process R&D team has expertise in developing and scaling up of multi step processes for complex chemistries like, heterocyclics, carbohydrates, organometallics, nucleosides, Polysaccharide chemistry with high molecular weight like 5000 Daltons ( Enoxaparin, Pentosan ) etc.
Alkylation and Acylation
Aminations (Reductive/Chiral)
Asymmetric Hydrogenations (Catalytic and hydrogen transfer)
Chiral synthesis
Grignard reactions
Organometallics (Alkyl Lithium/LDA)
Reductions using metal hydrides, Pd/C, Raney Nickel
Oxidations
Resolutions
Enzymatic chemistry
Nitration
Diazotization
Azidation
Sulfonation
Halogenations
Formylation and deformylation
Decarboxylation
The team is well versed in Process Development aspects like route scouting, alternate reagents, solvent selection, impurity profiling, catalyst screening etc. We also use QbD tools for identifying the CPPs/CMAs for developing products.